出生至12个月龄婴儿功能性胃肠症状的患病率及健康结局
Prevalence and Health Outcomes of Functional Gastrointestinal Symptoms in Infants From Birth to 12 Months of Age.
作者信息
Vandenplas Yvan, Abkari Abdelhak, Bellaiche Marc, Benninga Marc, Chouraqui Jean Pierre, Çokura FügenÇullu, Harb Tracy, Hegar Badriul, Lifschitz Carlos, Ludwig Thomas, Miqdady Mohamed, de Morais Mauro Batista, Osatakul Seksit, Salvatore Silvia, Shamir Raanan, Staiano Annamaria, Szajewska Hania, Thapar Nikhil
机构信息
*UZ Brussel, Vrije Universiteit Brussel, Brussels, Belgium †Unit of Pediatric Gastroenterology, University Hospital Ibn Rochd, Faculty of Medicine, University Hassan 2, Casablanca, Morocco ‡GI Unit, Robert Debre Hospital, Paris, France §Emma Children's Hospital/Academic Medical Center, Amsterdam, The Netherlands ||Gastroentérologie, Hépatologie et Nutrition, Clinique Universitaire de Pédiatrie, Grenoble Cedex 9, France ¶Pediatric Gastroenterology Hepatology and Nutrition, Cerrahpaşa Medical Faculty, University of Istanbul, Istanbul, Turkey #Children's Nutrition Research Centre, Queensland Children's Medical Research Institute, University of Queensland, Brisbane, Australia **Department of Child Health University of Indonesia, Jakarta, Indonesia ††Department of Pediatrics, Section of Gastroenterology, Hepatology, and Transplantation, Hospital Italiano, Buenos Aires, Argentina ‡‡Nutricia Research, Utrecht, The Netherlands §§Pediatric GI, Hepatology, and Nutrition, Sheikh Khalifa Medical City, Abu Dhabi, United Arab Emirates ||||Division of Pediatric Gastroenterology, Paulista School of Medicine, Federal University of São Paulo, Brazil ¶¶Department of Pediatrics, Faculty of Medicine, Prince of Songkla University, Hat Yai, Songkhla, Thailand ##Clinica Pediatrica, Università dell'Insubria, Varese, Italy ***Schneider Children's Medical Centre of Israel, Tel-Aviv University, Israel †††Department of Translational Medical Science, Section of Pediatrics, University of Naples Federico II, Naples, Italy ‡‡‡Department of Paediatrics, Medical University of Warsaw, Warsaw, Poland §§§Gastroenterology Unit, Great Ormond Street Hospital and UCL Institute of Child Health, London, UK.
出版信息
J Pediatr Gastroenterol Nutr. 2015 Nov;61(5):531-7. doi: 10.1097/MPG.0000000000000949.
OBJECTIVES
The aim of the study was to review published evidence and the opinion of practising clinicians on the prevalence and long-term health consequences of functional gastrointestinal symptoms in infants younger than 12 months.
METHODS
PubMed was searched from inception to November 2014 to find articles reporting the prevalence and long-term health outcomes of infantile colic, regurgitation, functional constipation, functional diarrhoea, and dyschezia in infants younger than <12 months. A questionnaire was sent to practising clinicians worldwide, and a group of 15 international experts met to discuss the likely frequency and longer-term consequences of these symptoms.
RESULTS
The literature search identified 30 studies reporting the prevalence of infantile colic (2%-73%), 13 that of regurgitation (3%-87%), 8 that of functional constipation (0.05%-39.3%), 2 that of functional diarrhoea (2%-4.1%), and 3 that of dyschezia (0.9%-5.6%). The studies varied in design, populations investigated, and definition of the symptoms. Questionnaires were received from 369 respondents. The experts agreed that the likely prevalences for colic, regurgitation, and functional constipation were 20%, 30%, and 15%, respectively. The limited data in the literature for functional diarrhoea and dyschezia suggest prevalences <10%. Infantile colic may be associated with future health problems in a subset of infants.
CONCLUSIONS
Functional gastrointestinal symptoms appear to occur in a significant proportion of infants younger than 12 months and may have an impact on future health outcomes. Prospective collection of data according to agreed criteria is needed to obtain more accurate estimates of the prevalence and consequences of these symptoms.
目的
本研究旨在回顾已发表的证据以及执业临床医生对于12个月以下婴儿功能性胃肠症状的患病率及其对长期健康影响的看法。
方法
检索了自数据库建立至2014年11月的PubMed，以查找报告12个月以下婴儿患婴儿腹绞痛、反流、功能性便秘、功能性腹泻和排便困难的患病率及长期健康结局的文章。向全球执业临床医生发送了一份调查问卷，并召集了15位国际专家组成的小组讨论这些症状可能的发生率及其长期后果。
结果
文献检索确定了30项报告婴儿腹绞痛患病率（2%-73%）的研究、13项报告反流患病率（3%-87%）的研究、8项报告功能性便秘患病率（0.05%-39.3%）的研究、2项报告功能性腹泻患病率（2%-4.1%）的研究以及3项报告排便困难患病率（0.9%-5.6%）的研究。这些研究在设计、所调查的人群以及症状定义方面存在差异。共收到369名受访者的调查问卷。专家们一致认为，腹绞痛、反流和功能性便秘的可能患病率分别为20%、30%和15%。文献中关于功能性腹泻和排便困难的有限数据表明患病率低于10%。在一部分婴儿中，婴儿腹绞痛可能与未来的健康问题相关。
结论
功能性胃肠症状似乎在很大比例的12个月以下婴儿中出现，并且可能对未来的健康结局产生影响。需要根据商定的标准前瞻性收集数据，以更准确地估计这些症状的患病率及其后果。
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