运用心理神经免疫学范式，对健康动态进行全面研究。

McCain Nancy L, Gray Dorothy Patricia, Walter Jeanne M, Robins JoLynne

Department of Adult Health, Virginia Commonwealth University, Richmond, VA 23298, USA.

ANS Adv Nurs Sci. 2005 Oct-Dec;28(4):320-32. doi: 10.1097/00012272-200510000-00004.

This article addresses psychoneuroimmunology (PNI) as an integrative paradigm for advancing both theoretical and empirical knowledge of physiological patterns that contribute to the dynamics of health. We depict relationships among relevant psychobehavioral and physiological components in a PNI-based framework. We then provide examples of how this framework guided 2 clinical trials designed to assess the effectiveness of selected nursing interventions to reduce stress and enhance coping, one in persons with human immunodeficiency viral disease and the other in persons with cancer. The examples address disease-specific measures for assessing the components of the PNI-based framework.

本文探讨心理神经免疫学（PNI），将其作为一种综合范式，以推进对有助于健康动态变化的生理模式的理论和实证认识。我们在基于PNI的框架中描述相关心理行为和生理成分之间的关系。然后，我们提供实例，说明该框架如何指导了两项临床试验，这两项试验旨在评估所选护理干预措施减轻压力和增强应对能力的有效性，一项针对感染人类免疫缺陷病毒疾病的患者，另一项针对癌症患者。这些实例涉及基于PNI框架各成分的疾病特异性评估措施。