School of Nursing, University of North Carolina, Chapel Hill, North Carolina, USA.
Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, North Carolina, USA.
J Adv Nurs. 2021 Apr;77(4):2073-2084. doi: 10.1111/jan.14742. Epub 2021 Jan 18.
This protocol directs a study that aims to: (a) describe the caregiver's experience over 8-12 weeks after an index adult patient's allogeneic bone marrow transplant (BMT) for advanced cancer using a case-oriented approach and mixed methods, with qualitative methods in the foreground; and (b) explore networks of relationships among psycho-neurological symptoms, positive psychological states and caregiver health.
Case-oriented longitudinal design using multiple data types and analytic approaches.
Data will be collected from 10-12 caregivers. The sample will be recruited from a large public hospital in the southeastern United States using maximum variation sampling (e.g., caregiver race/ethnicity, relationship to patient, age, education, and number of caregiving roles). Participants will be asked to complete weekly surveys, have their blood drawn bi-weekly and participate in an interview each month during the study period (~100 days). Aim 1 analysis will include directed content analysis and case-oriented visual analysis. Aim 2 analysis will include symptom network estimation of psycho-neurological symptoms, positive psychological states, and caregiver health. Institutional review board approval was obtained August 2018.
Results will provide an in-depth description of caregivers' experiences in the 100 days after BMT. Findings will inform generation of hypotheses and identification of targets for interventions to improve caregiver's experiences after BMT.
This in-depth multi-method longitudinal study to describe caregivers of adult patients receiving an allogeneic BMT is an essential step in understanding caregivers' complex responses to chronic stress and the role of positive psychological states. The results from this study will inform future research on chronic stress processes, intense caregiving, and intervention development.
本方案指导一项研究，旨在：(a)采用面向病例的方法和混合方法，以定性方法为主，描述成人患者在接受同种异体骨髓移植（BMT）治疗晚期癌症后 8-12 周内照顾者的经历；(b)探讨心理神经症状、积极心理状态和照顾者健康之间的关系网络。
采用面向病例的纵向设计，使用多种数据类型和分析方法。
将从 10-12 名照顾者中收集数据。采用最大变异抽样（例如照顾者的种族/民族、与患者的关系、年龄、教育程度和照顾角色的数量），从美国东南部的一家大型公立医院招募样本。参与者将被要求每周完成调查，每两周抽取一次血样，并在研究期间（约 100 天）每月接受一次访谈。目标 1 的分析将包括定向内容分析和面向病例的视觉分析。目标 2 的分析将包括心理神经症状、积极心理状态和照顾者健康的症状网络估计。机构审查委员会于 2018 年 8 月批准。
结果将深入描述 BMT 后 100 天照顾者的经历。研究结果将为假设的产生和确定改善 BMT 后照顾者体验的干预目标提供信息。
这项深入的多方法纵向研究旨在描述接受同种异体 BMT 的成年患者的照顾者，是了解照顾者对慢性应激的复杂反应以及积极心理状态作用的重要步骤。本研究的结果将为慢性应激过程、高强度护理和干预措施的发展提供信息。
