Sacchi C T, Pessoa L L, Ramos S R, Milagres L G, Camargo M C, Hidalgo N T, Melles C E, Caugant D A, Frasch C E
Adolfo Lutz Institute, São Paulo, Brazil.
J Clin Microbiol. 1992 Jul;30(7):1734-8. doi: 10.1128/jcm.30.7.1734-1738.1992.
Beginning in 1988, the incidence of meningococcal disease in the area of greater São Paulo began to surpass the upper confidence limit of an 8-year average incidence (from 1979 to 1986), thus characterizing a new epidemic in the region of greater São Paulo. This epidemic, which extended to 1990, was different from previous epidemics in that it was caused by serogroup B. The increased incidence of meningococcal disease was paralleled by an increased prevalence of a single group B clone, B:4:P1.15, of the ET-5 complex. ET-5 strains have been present in the greater São Paulo area since 1979; however, they have been associated with a high percentage of the group B disease only from 1987 to the present. On the basis of the increased incidence of group B disease in São Paulo, a mass vaccination program with a serotype 4:P1.15 meningococcal protein vaccine was undertaken. The impact of this vaccination program is under analysis.
自1988年起，大圣保罗地区的脑膜炎球菌病发病率开始超过8年平均发病率（1979年至1986年）的置信上限，从而标志着大圣保罗地区出现了一场新的疫情。这场疫情一直持续到1990年，与以往疫情不同的是，它是由B血清群引起的。脑膜炎球菌病发病率的上升与ET-5复合体中单一的B:4:P1.15 B血清群克隆株的流行率增加同时出现。自1979年以来，ET-5菌株就一直存在于大圣保罗地区；然而，仅从1987年至今，它们才与高比例的B血清群疾病相关联。基于圣保罗B血清群疾病发病率的上升，开展了一项使用4:P1.15血清型脑膜炎球菌蛋白疫苗的大规模疫苗接种计划。该疫苗接种计划的影响正在分析之中。
