Añíbarro B, Caballero T, García-Ara C, Díaz-Pena J M, Ojeda J A
Allergology Service, La Paz Hospital, Madrid, Spain.
J Allergy Clin Immunol. 1992 Jul;90(1):103-9. doi: 10.1016/s0091-6749(06)80016-3.
Sulfites have been implicated as the cause of bronchospasm in some subjects with asthma. However, there is still no universally accepted explanation of the pathogenesis of these reactions. We have studied five children with asthma with metabisulfite intolerance confirmed by oral challenge testing. The challenge test with metabisulfite was repeated after premedication of all the patients with 1.5 mg of oral cyanocobalamin. In four of the five patients treated with cyanocobalamin, bronchospasm did not develop in the second metabisulfite challenge. The possible mechanisms are discussed.
亚硫酸盐被认为是某些哮喘患者支气管痉挛的病因。然而，对于这些反应的发病机制仍没有一个被普遍接受的解释。我们研究了5名经口服激发试验确诊为焦亚硫酸盐不耐受的哮喘患儿。在所有患者口服1.5毫克氰钴胺进行预处理后，重复进行焦亚硫酸盐激发试验。在接受氰钴胺治疗的5名患者中，有4名在第二次焦亚硫酸盐激发试验中未发生支气管痉挛。文中讨论了可能的机制。
