特应性皮炎患者血浆中调节激活正常T细胞表达和分泌因子（RANTES）水平升高。
Elevated plasma RANTES levels in patients with atopic dermatitis.
作者信息
Yamada H, Chihara J, Matsukura M, Yasuba H, Yudate T, Tezuka T
机构信息
Department of Dermatology, Kinki University, Osaka, Japan.
出版信息
J Clin Lab Immunol. 1996;48(2):87-91.
Eosinophils and T cells are involved in the pathologic process of atopic dermatitis. To further understand the role of these cells, and the possible involvement of RANTES, in the pathogenesis of atopic dermatitis, we measured the plasma level of RANTES using the sandwich ELISA. The mean plasma level of RANTES in 11 patients with atopic dermatitis was significantly higher than that of 15 normal control subjects. RANTES levels were higher in patients with severe form of atopic dermatitis than that of patients with mild disease. These findings suggest that RANTES may play a role in the recruitment and activation of eosinophils and T cells in atopic dermatitis.
嗜酸性粒细胞和T细胞参与了特应性皮炎的病理过程。为了进一步了解这些细胞的作用以及RANTES可能的参与情况在特应性皮炎发病机制中的作用，我们使用夹心ELISA法测量了血浆中RANTES的水平。11例特应性皮炎患者的血浆RANTES平均水平显著高于15名正常对照受试者。重度特应性皮炎患者的RANTES水平高于轻度疾病患者。这些发现表明RANTES可能在特应性皮炎中嗜酸性粒细胞和T细胞的募集和激活中发挥作用。
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