Mochizuki Hitoshi, Ugawa Yoshikazu
Third Department of Internal Medicine, National Defense Medical College, Tokorozawa, Saitama, Japan.
Clin EEG Neurosci. 2005 Oct;36(4):278-84. doi: 10.1177/155005940503600407.
The recent revival of interest in high-frequency oscillation (HFO) is triggered by getting an opportunity to noninvasively monitor the timing of highly synchronized and rapidly repeating population spikes generated in the human somatosensory system. HFOs could be recorded from brainstem, cuneothalamic relay neurons, thalamus, thalamocortical radiation, thalamocortical terminals and cortex with deep brain or surface electrodes, or with magnetoencephalography. Here we briefly review the HFOs at each level of somatosensory pathways. HFOs recorded at brainstem might be produced by volume conduction from oscillations of the medial lemniscus. Thalamic HFOs at around 1000 Hz frequency would be generated within the somatosensory thalamus. Cortical HFOs would be generated by at least a few different mechanisms, thalamo-cortical projection terminals, interneurons and pyramidal cells of the primary sensory cortex. HFOs have been studied in several ways: their modulation by arousal changes, movements or drugs, their recovery function, effects of transcranial magnetic stimulation on them and also their changes in patients with various neurological diseases.
近期对高频振荡（HFO）兴趣的再度兴起，是因为有机会非侵入性地监测人类体感系统中产生的高度同步且快速重复的群体尖峰的时间。HFO可以通过深部脑电极或表面电极，或者通过脑磁图，从脑干、楔丘脑中继神经元、丘脑、丘脑皮质辐射、丘脑皮质终末和皮质记录下来。在此，我们简要回顾体感通路各水平的HFO。在脑干记录到的HFO可能是由内侧丘系振荡的容积传导产生的。频率约为1000Hz的丘脑HFO将在体感丘脑中产生。皮质HFO将由至少几种不同机制产生，包括丘脑皮质投射终末、初级感觉皮质的中间神经元和锥体细胞。人们已经通过多种方式对HFO进行了研究：它们受觉醒变化、运动或药物的调制、它们的恢复功能、经颅磁刺激对它们的影响，以及它们在各种神经系统疾病患者中的变化。
