Venkatesh Siddarth, Byrne Mark E, Peppas Nicholas A, Hilt J Zach
Biomedical Devices and Drug Delivery Laboratories, Department of Chemical Engineering, Auburn University, Auburn, AL 36849-5127, USA.
Expert Opin Drug Deliv. 2005 Nov;2(6):1085-96. doi: 10.1517/17425247.2.6.1085.
This review article highlights recent activities in the field of biomimetic systems and their application in controlled drug delivery. A definition and overview of biomimetic processes is given, with a focus on synthesis and assembly for the creation of novel biomaterials. In particular, systems are classified on the basis of three subsets, which include biological, biohybrid and synthetic structures. Examples focus on the current and proposed clinical significance for systems that mimic processes where the underlying molecular principles are well understood. Biomimetic materials and systems are presented as exceptional candidates for various controlled drug delivery applications and have enormous potential in medicine for the treatment of disease.
这篇综述文章重点介绍了仿生系统领域的近期活动及其在控释药物递送中的应用。给出了仿生过程的定义和概述,重点是用于创建新型生物材料的合成和组装。特别是,系统根据三个子集进行分类,包括生物、生物杂交和合成结构。实例聚焦于那些模仿基本分子原理已得到充分理解的过程的系统的当前和潜在临床意义。仿生材料和系统被视为各种控释药物递送应用的优秀候选者,在医学疾病治疗方面具有巨大潜力。