Cui Daxiang, Gao Huajian
Bio-Nano-Engineering Center, Max Planck Institute for Metals Research, D-70569, Stuttgart, Germany.
Biotechnol Prog. 2003 May-Jun;19(3):683-92. doi: 10.1021/bp025791i.
Over the past few years, bionanomaterial science has emerged as a new exciting field in which theoretical and experimental studies of structure and function of bionanomaterials have become a focus, and the importance of DNA, RNA, and peptides as bionanomaterials to the fundamental development in biology and nanomaterials has begun to be recognized. In particular, biochemistry, biophysics, biomechanics, thermodynamics, and electronic properties of DNA, RNA, and peptides, as well as intelligent composite biological materials, have become a new interdisciplinary frontier in life science and material science. There is an increasing need for a more systematic study of the basic issues involved in bionanomaterials and a more active participation of researchers in the application domain of such novel materials. Great advances have been and are being made in nanobiochip materials, nanoscale biomimetic materials, nanomotors, nanocomposite materials, interface biomaterials, and nanobiosensor and nano drug delivery systems, with enormous prospect in industrial, defense, and clinical medicine applications. Here we review some of the main advances in this field over the past few years, explore the application prospects, and discuss the concepts, issues, approaches, and challenges, with the aim of stimulating a broader interest in developing bionanomaterials technology.
在过去几年中，生物纳米材料科学已成为一个令人兴奋的新领域，其中生物纳米材料结构与功能的理论和实验研究成为焦点，并且DNA、RNA和肽作为生物纳米材料对生物学和纳米材料基础发展的重要性已开始得到认可。特别是，DNA、RNA和肽以及智能复合生物材料的生物化学、生物物理学、生物力学、热力学和电子特性，已成为生命科学和材料科学中的一个新的跨学科前沿领域。越来越需要对生物纳米材料所涉及的基本问题进行更系统的研究，并且研究人员需要更积极地参与这类新型材料的应用领域。纳米生物芯片材料、纳米级仿生材料、纳米马达、纳米复合材料、界面生物材料以及纳米生物传感器和纳米药物递送系统已经取得并正在取得巨大进展，在工业、国防和临床医学应用方面具有巨大前景。在此，我们回顾过去几年该领域的一些主要进展，探索应用前景，并讨论概念、问题、方法和挑战，旨在激发对开发生物纳米材料技术更广泛的兴趣。
