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对小鼠肺炎病毒融合糖蛋白编码基因的序列分析表明，副粘病毒融合糖蛋白中可能存在保守的二级结构元件。

Sequence analysis of the gene encoding the fusion glycoprotein of pneumonia virus of mice suggests possible conserved secondary structure elements in paramyxovirus fusion glycoproteins.

作者信息

Chambers P, Pringle C R, Easton A J

机构信息

Department of Biological Sciences, Warwick University, Coventry, U.K.

出版信息

J Gen Virol. 1992 Jul;73 ( Pt 7):1717-24. doi: 10.1099/0022-1317-73-7-1717.

DOI:10.1099/0022-1317-73-7-1717
PMID:1629698
Abstract

The gene encoding the fusion (F) glycoprotein of pneumonia virus of mice consists of 1657 bases and contains an open reading frame encoding 537 amino acids which is more similar to the F proteins of pneumoviruses than to those of other paramyxoviruses. Computer-assisted sequence analyses can be combined with data on the antigenicity of various F proteins to suggest a possible arrangement of secondary structure elements common to all pneumovirus and paramyxovirus F proteins.

摘要

编码小鼠肺炎病毒融合（F）糖蛋白的基因由1657个碱基组成，包含一个编码537个氨基酸的开放阅读框，该开放阅读框与肺病毒的F蛋白比与其他副粘病毒的F蛋白更为相似。计算机辅助序列分析可以与各种F蛋白的抗原性数据相结合，以推测所有肺病毒和副粘病毒F蛋白共有的二级结构元件的可能排列。

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