Lai Eric C H, Chan Wing Cheong, Ma Tony K F, Tang Alice P Y, Poon Cycles S P, Leong Heng Tat
Department of Surgery, North District Hospital, and Department of Surgery, Chinese University of Hong Kong, HKSAR, China.
Breast J. 2005 Nov-Dec;11(6):454-6. doi: 10.1111/j.1075-122X.2005.00127.x.
Idiopathic granulomatous mastitis (IGM) is a rare benign inflammatory disease of the breast that mimics carcinoma of the breast. Its etiology and treatment remain unclear. A retrospective review of nine women with histopathologic diagnosis of IGM was performed. The women had a mean follow-up of 18.7 months and a mean age of 45.7 years (range 32-83 years). The main presentation was breast mass (100%). Clinically and radiologically, 55.6% of the women were suspected to have malignancy. One patient was treated with lumpectomy without recurrence. Eight patients were treated with expectant management with close regular surveillance. No surgery was performed and no medications were given. Fifty percent of the patients had spontaneous complete resolution of disease after a mean interval of 14.5 months. These four patients had no recurrence. Fifty percent of patients had static disease. In conclusion, it is important to differentiate IGM from carcinoma of the breast. Tissue biopsy remains the gold standard to confirm the diagnosis. Expectant management with close regular surveillance is the treatment of choice.
特发性肉芽肿性乳腺炎（IGM）是一种罕见的乳腺良性炎症性疾病，易与乳腺癌相混淆。其病因及治疗方法尚不明确。对9例经组织病理学诊断为IGM的女性患者进行了回顾性研究。这些女性患者的平均随访时间为18.7个月，平均年龄为45.7岁（范围32 - 83岁）。主要表现为乳房肿块（100%）。在临床和影像学检查中，55.6%的女性被怀疑患有恶性肿瘤。1例患者接受了肿块切除术，无复发。8例患者接受了密切定期监测的期待治疗。未进行手术，也未给予药物治疗。50%的患者在平均14.5个月的间隔后疾病自发完全缓解。这4例患者无复发。50%的患者病情静止。总之，将IGM与乳腺癌相鉴别很重要。组织活检仍是确诊的金标准。密切定期监测的期待治疗是首选治疗方法。
