Sigal Leonard H
Gateway Immunosciences, Stockbridge, MA 01262, USA.
Microorganisms. 2025 Jul 7;13(7):1602. doi: 10.3390/microorganisms13071602.
Lyme disease has many different manifestations, including arthritis. There is no evidence that the pathogen expresses toxins, so the presence of the organism is insufficient to cause inflammation and disease. Thus, the interaction between the causative pathogen and the many human immune system mechanisms responding to the organism is the apparent cause of inflammation and tissue damage/dysfunction. This review discusses many of the aspects of the relationship between organisms and host responses to summarize the many means by which the immune response can cause the synovitis of Lyme arthritis.
莱姆病有许多不同的表现形式，包括关节炎。没有证据表明该病原体表达毒素，因此病原体的存在不足以引发炎症和疾病。因此，致病病原体与人体对该病原体做出反应的多种免疫系统机制之间的相互作用显然是炎症和组织损伤/功能障碍的原因。这篇综述讨论了病原体与宿主反应之间关系的诸多方面，以总结免疫反应导致莱姆关节炎滑膜炎的多种方式。
