人类树突状细胞对细胞内病原体猪布鲁氏菌、流产布鲁氏菌和羊布鲁氏菌的侵袭高度敏感。
High susceptibility of human dendritic cells to invasion by the intracellular pathogens Brucella suis, B. abortus, and B. melitensis.
作者信息
Billard Elisabeth, Cazevieille Chantal, Dornand Jacques, Gross Antoine
机构信息
INSERM U431, Université Montpellier II, cc100, Place E. Bataillon, 34095 Montpellier, France.
出版信息
Infect Immun. 2005 Dec;73(12):8418-24. doi: 10.1128/IAI.73.12.8418-8424.2005.
Abstract
Bacteria from the Brucella genus are able to survive and proliferate within macrophages. Because they are phylogenetically closely related to macrophages, myeloid dendritic cells (DCs) constitute potential targets for Brucella bacteria. Here we report that DCs display a great susceptibility to Brucella infection. Therefore, DCs might serve as a reservoir and be important for the development of Brucella bacteria within their host.
摘要
布鲁氏菌属的细菌能够在巨噬细胞内存活和增殖。由于它们在系统发育上与巨噬细胞密切相关，髓样树突状细胞（DCs）构成了布鲁氏菌的潜在靶标。在此我们报告，DCs对布鲁氏菌感染表现出极大的易感性。因此，DCs可能充当宿主内布鲁氏菌发育的储存库并发挥重要作用。
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