巨噬细胞对光滑型和粗糙型布鲁氏菌属的不同反应：与毒力的关系
Different responses of macrophages to smooth and rough Brucella spp.: relationship to virulence.
作者信息
Jiménez de Bagüés María P, Terraza Annie, Gross Antoine, Dornand Jacques
机构信息
Unidad de Sanidad Animal, Servicio de Investigación Agroalimentaria, Diputación General de Aragón, 50080 Zaragoza, Spain.
出版信息
Infect Immun. 2004 Apr;72(4):2429-33. doi: 10.1128/IAI.72.4.2429-2433.2004.
Abstract
By comparing smooth wild-type Brucella strains to their rough mutants, we show that the lipopolysaccharide (LPS) O side chain of pathogenic Brucella has a dramatic impact on macrophage activation. It favors the development of virulent Brucella by preventing the synthesis of immune mediators, important for host defense. We conclude that this O chain property is firmly linked to Brucella virulence.
摘要
通过将光滑的野生型布鲁氏菌菌株与其粗糙突变体进行比较，我们发现致病性布鲁氏菌的脂多糖（LPS）O侧链对巨噬细胞激活有显著影响。它通过阻止对宿主防御至关重要的免疫介质的合成，有利于毒性布鲁氏菌的发展。我们得出结论，这种O链特性与布鲁氏菌的毒力密切相关。
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