Varghese Linda R, Stanley Michael W, Lucido Mary Lynne, Mallery Shawn, Lai Rebecca, Bardales Ricardo H
Department of Pathology, Division of Gastroenerology, Hennepin County Medical Center, Minneapolis, Minnesota, USA.
Diagn Cytopathol. 2005 Dec;33(6):407-11. doi: 10.1002/dc.20362.
Malignant extra renal tumors with rhabdoid phenotype are aggressive neoplasms associated with a poor prognosis. These tumors have been reported in soft tissue and various organs including the gastrointestinal tract. We report one of such tumors arising in the esophagus and discuss the cytopathologic, immunohistochemical, and ultrastructural features. Endoscopic ultrasound-guided fine-needle aspiration (FNA) cytology revealed a highly cellular tumor, consisting of polygonal poorly cohesive cells with prominent eosinophilic paranuclear cytoplasmic inclusions. Immunohistochemical staining showed strong cytoplasmic positivity for vimentin and cytokeratin. Electron microscopy revealed presence of numerous intermediate filaments. To the best of our knowledge, this is the first example of carcinoma with rhabdoid phenotype of the esophagus diagnosed by FNA cytology.
具有横纹肌样表型的恶性肾外肿瘤是侵袭性肿瘤，预后不良。这些肿瘤已在软组织和包括胃肠道在内的各种器官中被报道。我们报告了一例发生在食管的此类肿瘤，并讨论其细胞病理学、免疫组织化学和超微结构特征。内镜超声引导下细针穿刺（FNA）细胞学检查显示肿瘤细胞高度密集，由多边形、细胞间黏附性差的细胞组成，伴有明显的嗜酸性核旁胞质包涵体。免疫组织化学染色显示波形蛋白和细胞角蛋白在细胞质中呈强阳性。电子显微镜检查发现存在大量中间丝。据我们所知，这是首例通过FNA细胞学诊断的食管横纹肌样表型癌。
