Pogacnik A, Zidar N
Department of Cytopathology, Institute of Oncology, Ljubljana, Zaloska, Slovenia.
Acta Cytol. 1997 Mar-Apr;41(2):539-43. doi: 10.1159/000332553.
Primary malignant rhabdoid tumor (MRT) of the liver is a rare tumor of early infancy, with a grim prognosis.
A 17-month-old female presented with a palpable mass in the upper right side of the abdomen. Ultrasonographically guided fine needle aspiration biopsy of the tumor contained malignant cells with medium-sized, vesicular nuclei; prominent nucleoli; and well-defined cytoplasm exhibiting paranuclear, dense inclusions. These inclusions reacted positively with cytokeratin and vimentin. Ultrastructural examination showed the presence of intermediate cytoplasmic filaments.
Cytomorphologic and immunocytochemical characteristics permit the preoperative differentiation of MRT from other malignant tumors of childhood. That facilitates treatment planning and precludes unnecessary surgical intervention.
肝脏原发性恶性横纹肌样瘤（MRT）是一种婴幼儿期罕见的肿瘤，预后不良。
一名17个月大的女性患儿，腹部右上侧可触及肿块。在超声引导下对肿瘤进行细针穿刺活检，发现恶性细胞，其细胞核中等大小、呈泡状，核仁突出，细胞质界限清晰，可见核旁致密包涵体。这些包涵体对细胞角蛋白和波形蛋白呈阳性反应。超微结构检查显示存在中间丝细胞质丝。
细胞形态学和免疫细胞化学特征有助于术前将MRT与儿童期其他恶性肿瘤区分开来。这有利于治疗方案的制定，避免不必要的手术干预。
