升麻地上部分环阿尔廷烷三萜类化合物的细胞毒性
Cytotoxicity of cycloartane triterpenoids from aerial part of Cimicifuga foetida.
作者信息
Tian Ze, Pan Rui Le, Si Jianyong, Xiao Pei Gen
机构信息
Institute of Medicinal Plant Development, Chinese Academy of Medical Science, Peking Union Medical College, Beijing, 100094, PR China.
出版信息
Fitoterapia. 2006 Jan;77(1):39-42. doi: 10.1016/j.fitote.2005.08.001. Epub 2005 Nov 21.
Our previous study had demonstrated cytotoxicity of EtOAc fraction from aerial part of Cimicifuga foetida on various cancer cell lines. In the present study, we investigated the cytotoxicity of five cycloartane triterpenoids isolated from the EtOAc fraction. Compounds (1,2,3) showed moderate cytotoxic activity on R-HepG2 cells and drug resistant sub line R-HepG2 but exhibited less toxicity against primary cultured normal mouse hepatocytes. Compounds (4) and (5) were inactive on all tested cell lines.
我们之前的研究已证明，升麻地上部分的乙酸乙酯提取物对多种癌细胞系具有细胞毒性。在本研究中，我们调查了从该乙酸乙酯提取物中分离出的五种环阿尔廷烷三萜类化合物的细胞毒性。化合物（1、2、3）对R-HepG2细胞和耐药亚系R-HepG2表现出中等细胞毒性活性，但对原代培养的正常小鼠肝细胞毒性较小。化合物（4）和（5）对所有测试细胞系均无活性。
Zotero 插件