Zhu Di-Fan, Zhu Guo-Lei, Kong Ling-Mei, Bao Ni-Man, Zhou Lin, Nian Yin, Qiu Ming-Hua
State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, 650201 China.
Nat Prod Bioprospect. 2015 Feb 19;5(2):61-67. doi: 10.1007/s13659-015-0053-7. eCollection 2015 Apr.
Four new 9,19-cycloartane triterpenoids, cimilactone E (), cimilactone F (), 2'--()-butenoyl-23--26-deoxyactein (), and 2',12--diacetylcimiracemonol-3---d-xylopyranoside (), together with four known constituents (-) were isolated from the roots of . The new structures were elucidated by extensive spectroscopic analysis. In addition, compounds and showed significant Wnt signaling pathway inhibitory activity, with IC values of 3.33 and 13.34 μM, respectively, using the luciferase reporter gene assay.
从[植物名称]的根部分离出了四种新的9,19-环阿尔廷三萜类化合物,即西米内酯E()、西米内酯F()、2'-()-丁烯酰基-23-去氧-26-脱氧乙酰升麻醇()和2',12-二乙酰基西米拉塞莫醇-3--D-吡喃木糖苷(),以及四种已知成分(-)。通过广泛的光谱分析阐明了这些新结构。此外,使用荧光素酶报告基因检测法,化合物和显示出显著的Wnt信号通路抑制活性,IC值分别为3.33和13.34 μM。