Buchsbaum Bradley R, Olsen Rosanna K, Koch Paul, Berman Karen Faith
National Institute of Mental Health, National Institutes of Health, Intramural Research Program, Department of Health and Human Services, Bethesda, Maryland 20892, USA.
Neuron. 2005 Nov 23;48(4):687-97. doi: 10.1016/j.neuron.2005.09.029.
To hear a sequence of words and repeat them requires sensory-motor processing and something more-temporary storage. We investigated neural mechanisms of verbal memory by using fMRI and a task designed to tease apart perceptually based ("echoic") memory from phonological-articulatory memory. Sets of two- or three-word pairs were presented bimodally, followed by a cue indicating from which modality (auditory or visual) items were to be retrieved and rehearsed over a delay. Although delay-period activation in the planum temporale (PT) was insensible to the source modality and showed sustained delay-period activity, the superior temporal gyrus (STG) activated more vigorously when the retrieved items had arrived to the auditory modality and showed transient delay-period activity. Functional connectivity analysis revealed two topographically distinct fronto-temporal circuits, with STG co-activating more strongly with ventrolateral prefrontal cortex and PT co-activating more strongly with dorsolateral prefrontal cortex. These argue for separate contributions of ventral and dorsal auditory streams in verbal working memory.
要听到一连串单词并重复它们，需要感觉运动处理以及更多的东西——临时存储。我们使用功能磁共振成像（fMRI）和一项旨在区分基于感知的（“回声式”）记忆与语音发音记忆的任务，来研究言语记忆的神经机制。以两种模式呈现两词或三词对的集合，随后给出一个提示，指示要从哪种模式（听觉或视觉）检索项目并在延迟期间进行复述。尽管颞平面（PT）在延迟期的激活对源模式不敏感且显示出持续的延迟期活动，但当检索到的项目来自听觉模式时，颞上回（STG）的激活更为强烈，并显示出短暂的延迟期活动。功能连接分析揭示了两个在地形上不同的额颞回路，其中STG与腹外侧前额叶皮层的共同激活更强，而PT与背外侧前额叶皮层的共同激活更强。这些结果表明腹侧和背侧听觉流在言语工作记忆中具有不同的作用。
