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自身免疫性胰腺炎:揭示一个隐匿的实体。

Autoimmune pancreatitis: unveiling a hidden entity.

作者信息

Wayne Michael, Delman Keith A, Kurt Tolga, Grossi Robert, Sabatini Maria, Cooperman Avram

机构信息

The Center for Biliary and Pancreatic Surgery at Cabrini Medical Center, New York, NY 10003, USA.

出版信息

Arch Surg. 2005 Nov;140(11):1104-7. doi: 10.1001/archsurg.140.11.1104.

DOI:10.1001/archsurg.140.11.1104
PMID:16301449
Abstract

HYPOTHESIS

After alcohol-induced and hereditary disease, idiopathic chronic pancreatitis is the most common cause of calcifying pancreatitis. This designation is used when no associated cause of chronic pancreatitis is found. We present 6 cases of idiopathic pancreatitis in which the postoperative pathological examination results demonstrated lymphoplasmacytic sclerosing pancreatitis or autoimmune pancreatitis.

DESIGN

Retrospective case series. The medical records of 6 patients referred and treated for autoimmune pancreatitis were reviewed. The duration of follow-up varies, the longest being 5 years. The disease and a literature review are reported.

SETTING

A 200-bed community hospital located in a large city. The patients were referred after being treated elsewhere for recurrent pancreatitis.

PATIENTS AND METHODS

Six patients with chronic recurrent pancreatitis were evaluated. They were selected because pathological review indicated that they all had autoimmune pancreatitis.

RESULTS

Six cases of lymphoplasmacytic sclerosing pancreatitis are presented and suggest that lymphoplasmacytic sclerosing pancreatitis should be thought of more often in chronic autoimmune pancreatitis.

CONCLUSION

Lymphoplasmacytic sclerosing pancreatitis is an increasingly recognized cause of chronic pancreatitis and should be considered in the evaluation of patients with chronic pancreatitis and no discernible cause.

摘要

假说

在酒精性和遗传性疾病之后,特发性慢性胰腺炎是钙化性胰腺炎最常见的病因。当未发现慢性胰腺炎的相关病因时,使用这一命名。我们报告6例特发性胰腺炎病例,其术后病理检查结果显示为淋巴细胞浆细胞性硬化性胰腺炎或自身免疫性胰腺炎。

设计

回顾性病例系列研究。对6例因自身免疫性胰腺炎转诊并接受治疗的患者的病历进行了回顾。随访时间各不相同,最长为5年。报告了该疾病及文献综述。

地点

位于大城市的一家拥有200张床位的社区医院。这些患者在其他地方因复发性胰腺炎接受治疗后被转诊至此。

患者和方法

对6例慢性复发性胰腺炎患者进行了评估。选择他们是因为病理检查表明他们均患有自身免疫性胰腺炎。

结果

报告了6例淋巴细胞浆细胞性硬化性胰腺炎病例,并提示在慢性自身免疫性胰腺炎中应更频繁地考虑淋巴细胞浆细胞性硬化性胰腺炎。

结论

淋巴细胞浆细胞性硬化性胰腺炎是慢性胰腺炎中一种日益被认识到的病因,在评估无明显病因的慢性胰腺炎患者时应予以考虑。

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Autoimmune pancreatitis: unveiling a hidden entity.自身免疫性胰腺炎:揭示一个隐匿的实体。
Arch Surg. 2005 Nov;140(11):1104-7. doi: 10.1001/archsurg.140.11.1104.
2
Lymphoplasmacytic sclerosing pancreato-cholangitis: a case report and review of the literature.淋巴浆细胞性硬化性胰胆管炎:一例病例报告并文献复习
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IgG4-related sclerosing lymphoplasmacytic pancreatitis and cholangitis mimicking carcinoma of pancreas and Klatskin tumour.IgG4相关性硬化性淋巴细胞性胰腺炎和胆管炎,酷似胰腺癌和肝门部胆管癌。
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IgG4-related retroperitoneal fibrosis and sclerosing cholangitis independent of autoimmune pancreatitis. A recurrent case after a 5-year history of spontaneous remission.IgG4相关性腹膜后纤维化和硬化性胆管炎,与自身免疫性胰腺炎无关。1例有5年自发缓解病史后复发的病例。
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[Lymphoplasmacytic sclerosing pancreatitis: a case report].[淋巴浆细胞性硬化性胰腺炎:一例报告]
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[Autoimmune pancreatitis with normal IgG4-Levels: 4 case reports and review of the literature].[IgG4水平正常的自身免疫性胰腺炎:4例病例报告及文献复习]
Z Gastroenterol. 2007 Dec;45(12):1245-51. doi: 10.1055/s-2007-963447.

引用本文的文献

1
Acute recurrent pancreatitis: an autoimmune disease?急性复发性胰腺炎:一种自身免疫性疾病?
World J Gastroenterol. 2008 Feb 21;14(7):999-1006. doi: 10.3748/wjg.14.999.
2
Clinical and radiologic resolution of IgG 4 normal, nonoperatively diagnosed lymphoplasmacytic sclerosing pancreatitis (LPSP) after initiation of steroid therapy.类固醇治疗开始后,IgG4正常、非手术诊断的淋巴细胞浆细胞性硬化性胰腺炎(LPSP)的临床及影像学缓解情况。
J Gastrointest Surg. 2007 Sep;11(9):1194-6. doi: 10.1007/s11605-006-0016-8.