Chen Yung-Jung, Fang Peng-Cheng
Department of Paediatrics, Medical College, National Cheng Kung University, Tainan, Taiwan.
Acta Paediatr. 2005 Nov;94(11):1615-8. doi: 10.1080/08035250500252609.
To investigate the sensory functions of the peripheral to central pathways in infants with Down syndrome (DS) by sensory evoked potentials.
Fifty-five infants, 30 DS infants and 25 controls, were examined by multimodal evoked potentials, including brainstem auditory evoked potentials (BAEP), visual evoked potentials (VEP) and short-latency somatosensory evoked potentials (SSEP).
No obvious difference was found in the peak latencies between the two groups for BAEP. Nine children with DS showed abnormal BAEP; six had hearing loss and three had prolonged wave I latencies. For VEP, the peak latencies of P(2) and N(2) were significantly longer and the amplitudes were smaller in the DS group than in the control group. Of the 30 infants with DS, five had significantly prolonged P(2) latencies and two had lower amplitudes. In SSEP, the mean latencies of N(20) and the interpeak latencies of N(13)-N(20) of the infants with DS showed apparent prolongation compared to the controls. Seven of 30 (23.3%) DS patients had prolonged N(20) latencies.
Our results indicate that various sensory deficits occur in patients with DS during the first year of life.
通过感觉诱发电位研究唐氏综合征（DS）婴儿外周至中枢通路的感觉功能。
55名婴儿，30名DS婴儿和25名对照者，接受了多模式诱发电位检查，包括脑干听觉诱发电位（BAEP）、视觉诱发电位（VEP）和短潜伏期体感诱发电位（SSEP）。
两组BAEP的峰潜伏期无明显差异。9名DS儿童BAEP异常；6名有听力损失，3名波I潜伏期延长。对于VEP，DS组的P（2）和N（2）峰潜伏期明显更长，波幅更小。30名DS婴儿中，5名P（2）潜伏期明显延长，2名波幅更低。在SSEP中，与对照组相比，DS婴儿的N（20）平均潜伏期和N（13）-N（20）峰间潜伏期明显延长。30名（23.3%）DS患者中有7名N（20）潜伏期延长。
我们的结果表明，DS患者在生命的第一年出现各种感觉缺陷。
