Janket S-J, Wightman A, Baird A E, Van Dyke T E, Jones J A
Department of General Dentistry, Boston University, Goldman School of Dental Medicine, 100 East Newton Street, Boston, MA 02118, USA.
J Dent Res. 2005 Dec;84(12):1154-9. doi: 10.1177/154405910508401212.
Previous analyses regarding effects of periodontal treatment on glycemic control included studies where causal association might not be assumed, or the results were reported non-quantitatively. We initiated this meta-analysis of 10 intervention studies to quantify the effects of periodontal treatment on HbA1c level among diabetic patients, to explore possible causes for the discrepant reports, and to make recommendations for future studies. Data sources were MEDLINE (January, 1980, to January, 2005), the EBMR, Cochrane Register, and bibliographies of the published articles. Three investigators extracted data regarding intervention, outcomes, and effect size. A total of 456 patients was included in this analysis, with periodontal treatment as predictor and the actual change in hemoglobin A1c level as the outcome. The weighted average decrease in actual HbA1c level was 0.38% for all studies, 0.66% when restricted to type 2 diabetic patients, and 0.71% if antibiotics were given to them. However, none was statistically significant.
先前关于牙周治疗对血糖控制影响的分析包括一些研究，在这些研究中可能无法假定因果关系，或者结果是非定量报告的。我们启动了这项对10项干预性研究的荟萃分析，以量化牙周治疗对糖尿病患者糖化血红蛋白（HbA1c）水平的影响，探索报告结果存在差异的可能原因，并为未来的研究提出建议。数据来源为MEDLINE（1980年1月至2005年1月）、循证医学评价数据库（EBMR）、Cochrane图书馆以及已发表文章的参考文献。三名研究人员提取了有关干预措施、结果和效应大小的数据。本分析共纳入456例患者，以牙周治疗作为预测因素，以糖化血红蛋白水平的实际变化作为结果。所有研究中糖化血红蛋白实际水平的加权平均下降率为0.38%，仅限于2型糖尿病患者时为0.66%，如果给予抗生素则为0.71%。然而，这些均无统计学意义。
