Sager Mark A, Hermann Bruce, La Rue Asenath
Wisconsin Alzheimer's Institute, Department of Medicine, University of Wisconsin-Madison, 53719, USA.
J Geriatr Psychiatry Neurol. 2005 Dec;18(4):245-9. doi: 10.1177/0891988705281882.
Adult children of persons with Alzheimer's disease are at increased risk of developing Alzheimer's disease because of hereditary, environmental, and health risk factors shared with affected parents. The Wisconsin Registry for Alzheimer's Prevention (WRAP) has completed baseline assessments on 452 middle-aged persons (mean = 53 years) who have at least 1 parent with AD. Forty-five percent had 1 or more apolipoprotein (APOE) epsilon4 alleles. There were few significant differences between epsilon4 carriers and noncarriers in demographics, health, and lifestyle measures or in neuropsychological performance. The high percentage of WRAP participants who are carriers of APOE epsilon4 underscores their increased risk for developing Alzheimer's disease, but the absence of differences related to APOE status and high mean scores on cognitive tests suggests that the APOE epsilon4 gene has yet to have a clinical impact on cognitive functioning. The WRAP cohort may be a valuable group to follow prospectively to characterize the nature of cognitive change in relation to risk factors and to identify underlying preclinical neurobiological changes.
阿尔茨海默病患者的成年子女由于与患病父母共享遗传、环境和健康风险因素，患阿尔茨海默病的风险增加。威斯康星州阿尔茨海默病预防登记处（WRAP）已对452名中年人士（平均年龄53岁）完成了基线评估，这些人至少有1名患阿尔茨海默病的父母。45%的人携带1个或更多的载脂蛋白（APOE）ε4等位基因。在人口统计学、健康和生活方式指标或神经心理学表现方面，ε4携带者和非携带者之间几乎没有显著差异。WRAP参与者中APOE ε4携带者的比例很高，这突出了他们患阿尔茨海默病风险的增加，但与APOE状态相关的差异不存在以及认知测试的平均高分表明，APOE ε4基因尚未对认知功能产生临床影响。WRAP队列可能是一个有价值的群体，可对其进行前瞻性跟踪，以描述与风险因素相关的认知变化的性质，并识别潜在的临床前神经生物学变化。
