下生殖道感染孕妇宫颈黏液中的宫颈炎性细胞因子及其他标志物。

Cervical inflammatory cytokines and other markers in the cervical mucus of pregnant women with lower genital tract infection.

作者信息

Sawada M, Otsuki K, Mitsukawa K, Yakuwa K, Nagatsuka M, Okai T

机构信息

Department of Obstetrics and Gynecology, Showa University School of Medicine, Shinagawa-ku, Tokyo, Japan.

出版信息

Int J Gynaecol Obstet. 2006 Feb;92(2):117-21. doi: 10.1016/j.ijgo.2005.10.004. Epub 2005 Nov 22.

DOI:10.1016/j.ijgo.2005.10.004

PMID:16307744

Abstract

OBJECTIVE

To evaluate concentrations of interleukin (IL)-6, IL-8, lactoferrin (LF), and alpha defencine (alpha-DF) in the cervical mucus of pregnant women and analyze their relation to cervicitis and bacterial vaginosis (BV).

METHODS

Cervical mucus samples were obtained from August 2003 through May 2004 from 157 women who were between the 6th and 36th week of an uncomplicated singleton pregnancy. All women were delivered at term, 69 without BV or cervicitis, 9 with BV, and 79 with cervicitis.

RESULTS

Interleukin 8, LF, and mu-DF concentrations were higher in women with cervicitis (0.81 +/- 0.36 pg/mL, 14.8+/-12.3 microg/mL, and 0.60 +/- 0.49 microg/mL) than in women without BV or cervicitis (0.35 +/- 0.34 pg/mL, 8.0 +/- 11.0 microg/mL, and 0.15 +/- 0.12 microg/mL). Interleukin 6 concentration was higher in women with BV (0.26 +/- 0.32 pg/mL) than in women without BV or cervicitis (0.09 +/- 0.15 pg/mL) or in women with cervicitis (0.12 +/- 0.18 pg/mL).

CONCLUSIONS

Higher levels of inflammatory cytokines in the cervical mucus of pregnant women may lead to early detection of lower genital tract infection.

摘要

目的

评估孕妇宫颈黏液中白细胞介素（IL）-6、IL-8、乳铁蛋白（LF）和α-防御素（α-DF）的浓度，并分析它们与宫颈炎和细菌性阴道病（BV）的关系。

方法

2003年8月至2004年5月期间，从157例单胎妊娠、孕期6至36周且无并发症的孕妇中获取宫颈黏液样本。所有孕妇均足月分娩，其中69例无BV或宫颈炎，9例有BV，79例有宫颈炎。

结果

宫颈炎患者的白细胞介素8、LF和μ-DF浓度（分别为0.81±0.36 pg/mL、14.8±12.3 μg/mL和0.60±0.49 μg/mL）高于无BV或宫颈炎的患者（分别为0.35±0.34 pg/mL、8.0±11.0 μg/mL和0.15±0.12 μg/mL）。BV患者的白细胞介素6浓度（0.26±0.32 pg/mL）高于无BV或宫颈炎的患者（0.09±0.15 pg/mL）以及有宫颈炎的患者（0.12±0.18 pg/mL）。