小泛素样修饰物（SUMO）改变Sox蛋白以实现发育多样性。

SUMO changes Sox for developmental diversity.

作者信息

Gill Grace

机构信息

Department of Pathology, Harvard Medical School, 77 Avenue Louis Pasteur, Boston, Massachusetts 02115, USA.

出版信息

Mol Cell. 2005 Nov 23;20(4):495-6. doi: 10.1016/j.molcel.2005.11.004.

DOI:10.1016/j.molcel.2005.11.004

PMID:16307912

Abstract

The finding that posttranslational modification of the SoxE transcription factors by SUMO regulates specific developmental programs (Taylor and LaBonne [2005], in the journal Developmental Cell) highlights the biological significance of SUMOylation in gene expression and underscores how much there is yet to learn about the function and regulation of this modification.

摘要

小泛素样修饰蛋白（SUMO）对SoxE转录因子进行的翻译后修饰可调节特定的发育程序（《发育细胞》杂志上泰勒和拉博纳于2005年发表的研究），这一发现凸显了SUMO化在基因表达中的生物学意义，并强调了对于这种修饰的功能和调控仍有许多有待了解之处。