Brinck Ulrich, Cordon-Cardo Carlos, Stachura Jerzy, Bortkiewicz Pawel, Fischer Gösta, Korabiowska Monika
Department of Pathology, Reinhard Nieter Hospital, Wilhelmshaven, Academic Hospital of the University Göttingen, Friedrich Paffrath Str. 100, 26389 Wilhelmshaven, Germany.
Anticancer Res. 2005 Nov-Dec;25(6B):4293-8.
The proposed grading system for malignant fibrous histiocytomas (MFH) comprises 3 grades of malignancy. Analogous to other grading systems, the system includes the factors of mitotic rate and necrosis. In addition to these two factors, the concept of cellularity was included. The prognostic relevance of the grading systems published by Costa, Coindre, van Unnik, Pezzi and Tsujimoto as well as the grading system proposed by the present study was tested on 161 MFH. The results showed that all grading systems tested produced clearly significant differences (p < 0.01) with regard to the survival estimated for patients with various grades of malignancy. These results revealed the superiority of systems that use 3 grades of malignancy over a 2-grade classification. The proposed grading system yielded a lower percentage of grade II tumours (37%) than the grading systems of Coindre (60%) and van Unnik (70%). In the multivariate analysis of all grading systems, the proposed grading system was the only one to show prognostic relevance (p < 0. 05).
提议的恶性纤维组织细胞瘤（MFH）分级系统包括3个恶性等级。与其他分级系统类似，该系统包含有丝分裂率和坏死等因素。除这两个因素外，还纳入了细胞密度的概念。在161例MFH病例中对科斯塔、宽德、范乌尼克、佩兹和辻本发表的分级系统以及本研究提议的分级系统的预后相关性进行了检验。结果显示，所有检验的分级系统在不同恶性等级患者的生存估计方面均产生了明显的显著差异（p < 0.01）。这些结果揭示了采用3个恶性等级的系统优于二级分类系统。提议的分级系统中II级肿瘤的比例（37%）低于宽德（60%）和范乌尼克（70%）的分级系统。在对所有分级系统的多变量分析中，提议的分级系统是唯一显示出预后相关性的系统（p < 0.05）。
