Ena P, Pinna A, Carta F
Institutes of Dermatology, andOphthalmology, University of Sassari, Sassari, Italy.
Clin Exp Dermatol. 2006 Jan;31(1):77-9. doi: 10.1111/j.1365-2230.2005.01988.x.
Lower eyelid involvement occurs in 6% of patients with discoid lupus erythematosus (DLE). Eyelid lesions are rarely the initial manifestation of DLE. We describe a 25-year-old woman presenting with discoid lesions of the lower eyelids, staphylococcal blepharitis and Meibomian gland dysfunction, who later developed a discoid lesion on the chin. Histopathological and immunofluorescence studies of a biopsy specimen from this lesion established the diagnosis of DLE. We are unaware of any previously reported cases of DLE presenting with discoid eyelid lesions associated with staphylococcal blepharitis and Meibomian gland dysfunction. DLE should be considered as a differential diagnosis in chronic blepharitis that persists despite usual medical management and eyelid hygiene. Misdiagnosis may lead to eyelid margin deformities, necessitate a complicated full-thickness biopsy, and delay diagnosis of systemic lupus.
盘状红斑狼疮（DLE）患者中6%会出现下眼睑受累。眼睑病变很少是DLE的初始表现。我们描述了一名25岁女性，其下眼睑出现盘状病变、葡萄球菌性睑缘炎和睑板腺功能障碍，随后下巴出现了盘状病变。对该病变活检标本进行的组织病理学和免疫荧光研究确诊为DLE。我们未发现之前有任何关于DLE伴有与葡萄球菌性睑缘炎和睑板腺功能障碍相关的盘状眼睑病变的报道。对于经常规药物治疗和眼睑卫生护理后仍持续存在的慢性睑缘炎，应考虑DLE作为鉴别诊断。误诊可能导致眼睑边缘畸形，需要进行复杂的全层活检，并延误系统性红斑狼疮的诊断。
