Christoffersen T, Berg T
Biochim Biophys Acta. 1975 Jan 13;381(1):72-7. doi: 10.1016/0304-4165(75)90190-7.
The hormone control of cyclic AMP-formation in isolated parenchymal liver cells from rats fed the carcinogen 2-acetylaminofluorene (0.025% for 4-8 weeks) was studied. The cells from the carcinogen-treated animals responded much more strongly to adrenergic agents than cells from control animals, while no significant difference was found for the glucagon effect. Of the adrenergic substances studied, the order of potency was isoprenalin larger than or equal to adrenalin larger than phhenylephrine; stimulation was blocked by propranolol, but not by phentolamine. The effects of supramaximal concentrations of isoprenalin and glucagon were not additive.
研究了喂食致癌物2-乙酰氨基芴（0.025%，持续4 - 8周）的大鼠分离的肝实质细胞中环磷酸腺苷（cAMP）形成的激素控制情况。与对照动物的细胞相比，经致癌物处理动物的细胞对肾上腺素能药物的反应要强得多，而胰高血糖素的作用未发现显著差异。在所研究的肾上腺素能物质中，效力顺序为异丙肾上腺素≥肾上腺素＞去氧肾上腺素；刺激被普萘洛尔阻断，但不被酚妥拉明阻断。超最大浓度的异丙肾上腺素和胰高血糖素的作用不是相加的。
