DNA从B型到Z型转变的静电学简单解释。
A simple explanation of the electrostatics of the B-to-Z transition of DNA.
作者信息
Guéron M, Demaret J P
机构信息
Groupe de Biophysique, Ecole Polytechnique, Palaiseau, France.
出版信息
Proc Natl Acad Sci U S A. 1992 Jul 1;89(13):5740-3. doi: 10.1073/pnas.89.13.5740.
Whereas the phosphates of B-DNA jut out into the solution, those of Z-DNA, being closer to DNA matter, are less subject to electrostatic screening by counterions. We present simple planar models of B- and Z-DNA that reflect these geometric features. The ionic strength dependence of the difference in the Poisson-Boltzmann electrostatic free energy of the models agrees with that measured by Pohl [Pohl, F. M. (1983) Cold Spring Harbor Symp. Quant. Biol. 47, 113-118]. This indicates that the electrostatics of the B-to-Z transition are primarily controlled by a qualitative geometrical difference and not by details of the DNA geometry or by complex electrostatic properties of the ionic solution.
B - DNA的磷酸基团伸向溶液中，而Z - DNA的磷酸基团更靠近DNA物质，因此较少受到抗衡离子的静电屏蔽。我们提出了反映这些几何特征的B - DNA和Z - DNA简单平面模型。模型的泊松 - 玻尔兹曼静电自由能差异对离子强度的依赖性与Pohl [Pohl, F. M. (1983) Cold Spring Harbor Symp. Quant. Biol. 47, 113 - 118] 所测量的结果一致。这表明B - 到Z转变的静电作用主要由定性的几何差异控制，而非由DNA几何结构的细节或离子溶液复杂的静电性质控制。
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