Kang Hyun-Mi, Ryong Kim Ju, Jeong Tae-Sook, Choi Sung-Gyu, Ryu Young-Han, Taeg Oh Goo, Baek Nam-In, Kwon Byoung-Mog
Korea Research Institute of Bioscience and Biotechnology, 52 Uendong, Yusung, Taejon 305-600, Republic of Korea.
Nat Prod Res. 2006 Feb;20(2):139-43. doi: 10.1080/14786410500045895.
Two cyclic diarylheptanoids, garugamblin-3 (1) and acerogenin L (2), isolated from the MeOH extract of the fruits of Alnus japonica Steud., inhibited human low-density lipoprotein (LDL) oxidation in the thiobarbituric acid-reactive substance assay with IC50 values of 2.9 and 1.7 microM, respectively, and they also inhibited cell-mediated LDL oxidation more than five times more strongly than that of a well-known antioxidant, probucol, at a concentration of 10 microM. 1 had no effect on the anti-atherogenesis in low-density lipoprotein receptor- deficient mice.
从日本桤木果实的甲醇提取物中分离得到的两种环状二芳基庚烷类化合物，garugamblin-3（1）和acerogenin L（2），在硫代巴比妥酸反应物质测定中抑制人低密度脂蛋白（LDL）氧化，IC50值分别为2.9和1.7 microM，并且在10 microM浓度下，它们对细胞介导的LDL氧化的抑制作用比著名的抗氧化剂普罗布考强五倍以上。化合物1对低密度脂蛋白受体缺陷小鼠的抗动脉粥样硬化作用没有影响。
