Sati Sushil Chandra, Sati Nitin, Sati O P
Department of Chemistry, H.N.B. Garhwal University, Srinagar Garhwal, Uttarakhand, India.
Pharmacogn Rev. 2011 Jul;5(10):174-83. doi: 10.4103/0973-7847.91115.
The genus Alnus has been reviewed for its chemical constituents and biological activities including traditional importance of some common species. The plants of this genus contain terpenoids, flavonoids, diarylheptanoids, phenols, steroids, and tannins. Diarylheptanoids are the dominant constituents within the genus Alnus, few of them exhibited antioxidant effects and inhibitory activity against nuclear factor kappaB activation, nitric oxide and tumor necrosis factor-α production, human umbilical vein endothelial cells, farnesyl protein transferase, cell-mediated low-density lipoprotein oxidation, HIF-1 in AGS cells, and the HIV-1-induced cytopathic effect in MT-4 cells. Some ellagitannines showed hepatoprotective activity even in a dose of 1 mg/kg which is ten-fold smaller compared with the dose of traditional flavonoid-based drugs. The members of genus Alnus are well known for their traditional uses in the treatment of various diseases like cancer, hepatitis, inflammation of uterus, uterine cancer, rheumatism, dysentery, stomachache, diarrhea, fever, etc. The aim of the present review is to summarize the various researches related to the chemistry and pharmacology of genus Alnus.
已对桤木属植物的化学成分和生物活性进行了综述，包括一些常见物种的传统重要性。该属植物含有萜类化合物、黄酮类化合物、二芳基庚烷类化合物、酚类、甾体和单宁。二芳基庚烷类化合物是桤木属植物中的主要成分，其中少数表现出抗氧化作用以及对核因子κB激活、一氧化氮和肿瘤坏死因子-α产生、人脐静脉内皮细胞、法尼基蛋白转移酶、细胞介导的低密度脂蛋白氧化、AGS细胞中的缺氧诱导因子-1以及MT-4细胞中HIV-1诱导的细胞病变效应的抑制活性。一些鞣花单宁即使在1mg/kg的剂量下也显示出肝脏保护活性，该剂量比传统的基于黄酮类药物的剂量小十倍。桤木属植物成员因其在治疗各种疾病（如癌症、肝炎、子宫炎症、子宫癌、风湿病、痢疾、胃痛、腹泻、发烧等）方面的传统用途而闻名。本综述的目的是总结与桤木属植物化学和药理学相关的各种研究。
