绵参新苷：一种来自绵参的新型呋喃贝壳杉烷二萜糖苷。

Eremostachiin: a new furanolabdane diterpene glycoside from Eremostachys glabra.

作者信息

Delazar Abbas, Modarresi Masoud, Shoeb Mohammad, Nahar Lutfun, Reid Raymond G, Kumarasamy Yashodharan, Majinda Runner R T, Sarker Satyajit D

机构信息

School of Pharmacy, Tabriz University of Medical Sciences, Tabriz, Iran.

出版信息

Nat Prod Res. 2006 Feb;20(2):167-72. doi: 10.1080/13518470500047082.

DOI:10.1080/13518470500047082

PMID:16319011

Abstract

The reversed-phase preparative HPLC analysis of the methanol extract of the rhizomes of Eremostachys glabra (Lamiaceae) led to the isolation of two furanolabdane diterpene glycosides, phlomisoside II, and beta-D-glucopyranosyl-(1-->2)-beta-D-glucopyranosyl ester of phlomisoic acid (named eremostachiin), the latter being a novel natural product. The structure of the new compound has been elucidated unambiguously by HRMS and a series of 1D- and 2D-NMR spectroscopic techniques. The free radical scavenging activity of these compounds was assessed using the DPPH assay.

摘要

对糙苏（唇形科）根茎甲醇提取物进行反相制备高效液相色谱分析，分离得到两种呋喃贝壳杉烷二萜糖苷，即糙苏苷II和糙苏酸的β-D-吡喃葡萄糖基-(1→2)-β-D-吡喃葡萄糖基酯（命名为糙苏素），后者是一种新型天然产物。通过高分辨质谱和一系列一维及二维核磁共振光谱技术明确阐明了该新化合物的结构。使用DPPH法评估了这些化合物的自由基清除活性。