Folsom Aaron R, Hong Ching-Ping
Division of Epidemiology and Community Health, School of Public Health, University of Minnesota, Minneapolis, MN, USA.
Am J Epidemiol. 2006 Feb 1;163(3):232-5. doi: 10.1093/aje/kwj037. Epub 2005 Nov 30.
A recent prospective study among Swedish women suggested an inverse association of dietary magnesium intake with incidence of colorectal cancer. The authors assessed this association in a cohort of 35,196 Iowa women initially free of cancer and aged 55-69 years in 1986. Intakes of magnesium and other nutrients were assessed by food frequency questionnaire at baseline. Over 17 years of follow-up through 2002, 1,112 women developed colorectal cancer. After adjustment for age, energy, other nutrients, and risk factors for colorectal cancer, the hazard ratios of colorectal cancer across quintiles of magnesium intake were 1.00, 0.96, 0.83, 0.87, and 0.80 (95% confidence interval: 0.62, 1.03; p(trend) = 0.06). The association was largely absent for rectal cancer but, for colon cancer, the hazard ratios were 1.00, 1.00, 0.88, 0.85, and 0.77 (95% confidence interval: 0.58, 1.03; p(trend) = 0.04). These findings offer further evidence that a diet high in magnesium may reduce the occurrence of colon cancer among women. If replicated by other observational studies, a clinical trial would be needed to determine whether it is magnesium, specifically, and not other aspects of the contributing foods, that may offer benefit.
瑞典女性近期的一项前瞻性研究表明，膳食镁摄入量与结直肠癌发病率呈负相关。作者在1986年对35196名爱荷华州55至69岁、最初无癌症的女性队列中评估了这种关联。在基线时通过食物频率问卷评估镁和其他营养素的摄入量。在截至2002年的17年随访中，1112名女性患了结直肠癌。在对年龄、能量、其他营养素和结直肠癌危险因素进行调整后，镁摄入量五分位数组的结直肠癌风险比分别为1.00、0.96、0.83、0.87和0.80（95%置信区间：0.62，1.03；p趋势=0.06）。直肠癌基本不存在这种关联，但对于结肠癌，风险比分别为1.00、1.00、0.88、0.85和0.77（95%置信区间：0.58，1.03；p趋势=0.04）。这些发现进一步证明，高镁饮食可能会降低女性患结肠癌的几率。如果其他观察性研究能够重复这些结果，则需要进行一项临床试验来确定是否是镁本身，而不是相关食物的其他方面，可能带来益处。
