致力于解决非裔美国人的心血管健康差异问题：杰克逊心脏研究的设计与方法
Toward resolution of cardiovascular health disparities in African Americans: design and methods of the Jackson Heart Study.
作者信息
Taylor Herman A, Wilson James G, Jones Daniel W, Sarpong Daniel F, Srinivasan Asoka, Garrison Robert J, Nelson Cheryl, Wyatt Sharon B
机构信息
School of Medicine and the Examination Center, Jackson Heart Study, University of Mississippi Medical Center, Jackson 39216-4505, USA.
出版信息
Ethn Dis. 2005 Autumn;15(4 Suppl 6):S6-4-17.
OBJECTIVE
The design, overall methods, and major phenotypes for the all-African-American Jackson Heart Study (JHS) are detailed.
METHODS
Participants were enrolled from the three counties that make up the Jackson, Mississippi metropolitan area. Relatives of selected participants were recruited to develop a large, nested family cohort. Participants provided extensive medical and social history, had an array of physical and biochemical measurements and diagnostic procedures, and provided genomic DNA.
RESULTS
Data and biologic materials have been collected from 5302 adult African Americans, including 1499 members of 291 families. Participants have a high prevalence of diabetes, hypertension, obesity, and related disorders.
DISCUSSION
The JHS dataset and biologic materials (serum, DNA, and cryopreserved cells) offer a valuable resource for the study of diseases that are of particular importance to African Americans.
目的
详细介绍全非裔美国人杰克逊心脏研究（JHS）的设计、总体方法和主要表型。
方法
参与者来自构成密西西比州杰克逊市大都市区的三个县。招募选定参与者的亲属以建立一个大型的嵌套家庭队列。参与者提供了广泛的医学和社会史，进行了一系列身体和生化测量及诊断程序，并提供了基因组DNA。
结果
已从5302名成年非裔美国人中收集了数据和生物材料，其中包括291个家庭的1499名成员。参与者中糖尿病、高血压、肥胖症及相关疾病的患病率很高。
讨论
JHS数据集和生物材料（血清、DNA和冷冻保存的细胞）为研究对非裔美国人特别重要的疾病提供了宝贵资源。
Zotero 插件