非裔美国人中的性别、体重状况和慢性肾脏病：杰克逊心脏研究。
Sex, weight status, and chronic kidney disease among African Americans: the Jackson Heart Study.
机构信息
Mississippi Institute for the Improvement of Geographic Minority Health, University of Mississippi Medical Center, Jackson, MS 39216, USA.
出版信息
J Investig Med. 2013 Apr;61(4):701-7. doi: 10.2310/JIM.0b013e3182880bf5.
BACKGROUND
Obesity has been shown to have implications for chronic kidney disease (CKD); however, it has received minimal attention from scientists studying CKD among African Americans.
OBJECTIVES
The purpose of this study was to examine the manner in which weight status has implications for CKD among this group through analysis of data drawn from the Jackson Heart Study (JHS).
DESIGN
Cross-sectional analysis of a single-site longitudinal population-based cohort.
PARTICIPANTS
The data for this study were drawn from the baseline examination of the Jackson Heart Study (JHS). The analytic cohort consisted of 3430 African American men and women (21-84 years of age) living in the tricounty area of the Jackson, Mississippi metropolitan areas with complete data to determine CKD status.
MAIN MEASUREMENTS
The primary dependent variable was CKD (defined as the presence of albuminuria or reduced estimated glomerular filtration rate <60 mL/min per 1.73 m(2)). Weight status, the primary predictor, was a 4-category measure based on body mass index.
RESULTS
Associations were explored through bivariable analyses and multivariable logistic regression analyses adjusting for CKD, weight status, diabetes, hypertension, and cardiovascular disease risk factors as well as demographic factors. The prevalence of CKD in the JHS was 20%. The proportion of overweight, class I, and class II obese individuals was 32.5%, 26.9%, and 26.2% respectively. In the pooled model, weight status was not found to be associated with CKD; however, subgroup analysis revealed that class II obesity was associated with CKD among men (odds ratio, 2.37; confidence interval, 1.34-4.19) but not among women (odds ratio, 1.32; confidence interval, 0.88-1.98). The relationship between CKD prevalence and diabetes and CKD prevalence and hypertension varied by sex and differed across weight categories.
CONCLUSIONS
Weight status has implications for CKD among the JHS participants, and this study underscores the need for additional research investigating the relationship between weight status, sex, and CKD among African Americans.
背景
肥胖与慢性肾脏病（CKD）有关；然而，在研究非裔美国人 CKD 的科学家那里，它几乎没有受到关注。
目的
本研究的目的是通过分析来自杰克逊心脏研究（JHS）的数据，研究体重状况对该人群 CKD 的影响方式。
设计
单站点纵向基于人群的队列的横断面分析。
参与者
本研究的数据来自杰克逊心脏研究（JHS）的基线检查。分析队列由密西西比州杰克逊大都市地区三县的 3430 名非裔美国男性和女性（21-84 岁）组成，他们具有完整的数据来确定 CKD 状况。
主要测量
主要因变量是 CKD（定义为白蛋白尿或估计肾小球滤过率<60mL/min/1.73m2）。体重状况，主要预测因子，是基于体重指数的 4 类测量。
结果
通过双变量分析和多变量逻辑回归分析探索关联，调整 CKD、体重状况、糖尿病、高血压和心血管疾病危险因素以及人口统计学因素。JHS 的 CKD 患病率为 20%。超重、I 类和 II 类肥胖的比例分别为 32.5%、26.9%和 26.2%。在汇总模型中，体重状况与 CKD 无关；然而，亚组分析显示，II 类肥胖与男性 CKD 相关（优势比，2.37；置信区间，1.34-4.19），但与女性无关（优势比，1.32；置信区间，0.88-1.98）。糖尿病和 CKD 患病率以及高血压和 CKD 患病率之间的关系因性别而异，并且在体重类别之间存在差异。
结论
体重状况对 JHS 参与者的 CKD 有影响，本研究强调需要进一步研究非裔美国人中体重状况、性别和 CKD 之间的关系。
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