Plourd David M, Austin Katherine
Department of Obstetrics and Gynecology, Naval Medical Center, San Diego, California, USA.
J Reprod Med. 2005 Oct;50(10):779-83.
To evaluate to what degree a positive verbal history of prior chickenpox infection correlates with current immunity.
Patients presenting for prenatal registration at Naval Medical Center, San Diego, from January through June 2002 were candidates to participate in the study. Each patient was asked about her personal history of chickenpox. A blood sample was then obtained for an enzyme-linked immunosorbent assay IgG antibody test.
Results were obtained on 1,085 patients. Of the 940 evaluable patients who reported a positive history of varicella, 904 (96.2%) were serologically immune; 21 (2.2%) of them had a negative antibody titer, and 15 (1.6%) of them had an equivocal titer. The overall seronegativity rate was 4.14% for all patients enrolled.
There is a strong correlation between a reported history of chickenpox and serum immunity. Universal screening does not seem necessary, but education of susceptible individuals is warranted.
评估既往水痘感染的阳性口头病史与当前免疫力的相关程度。
2002年1月至6月在圣地亚哥海军医疗中心进行产前登记的患者为参与本研究的对象。每位患者均被询问其水痘个人病史。随后采集血样进行酶联免疫吸附测定IgG抗体检测。
共获得1085例患者的结果。在报告有水痘阳性病史的940例可评估患者中，904例（96.2%）血清学免疫；其中21例（2.2%）抗体滴度为阴性，15例（1.6%）滴度不明确。所有入组患者的总体血清阴性率为4.14%。
报告的水痘病史与血清免疫力之间存在很强的相关性。普遍筛查似乎没有必要，但对易感个体进行教育是有必要的。
