年轻成年人对水痘带状疱疹病毒的免疫力：在水痘疫苗广泛接种之前出现下降。
Immunity to varicella zoster virus among young adults: a decline prior to widespread uptake of varicella vaccines.
作者信息
Grotto I, Balicer R D, Smetana Z, Davidovitch N, Bar-Zeev Y, Mendelson E, Zarka S, Huerta M
机构信息
Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva, Israel.
出版信息
Infection. 2008 Mar;36(2):130-4. doi: 10.1007/s15010-007-7192-7. Epub 2008 Mar 31.
BACKGROUND
The epidemiology of chickenpox in Israel is changing, mainly due to the increasing - but not universal - uptake of varicella vaccine.
PATIENTS AND METHODS
We conducted a seroprevalence study of varicella zoster virus (VZV) antibodies among 536 Israeli military recruits 18 years of age, on the basis of a representative sample of sera collected in 2003.
RESULTS
The overall seroprevalence rate was 94.6%, which was significantly lower than that observed in a similar population in 1992 (98.4%, p < 0.001). The rate was lower among subjects whose fathers had less than 12 years of schooling (89.8%, p = 0.033). No statistically significant differences were observed when data were stratified by sex, subject's level of education, or origin.
CONCLUSION
This decline in the level of immunity must be considered when determining pre- and post-exposure vaccination policy among young adults in crowded environments.
背景
以色列水痘的流行病学正在发生变化，主要原因是水痘疫苗接种率上升，但尚未普及。
患者与方法
我们基于2003年收集的血清代表性样本，对536名18岁的以色列新兵进行了水痘带状疱疹病毒（VZV）抗体血清流行率研究。
结果
总体血清流行率为94.6%，显著低于1992年在类似人群中观察到的流行率（98.4%，p<0.001）。父亲受教育年限少于12年的受试者中该比率较低（89.8%，p = 0.033）。按性别、受试者教育水平或籍贯分层数据时，未观察到统计学上的显著差异。
结论
在确定拥挤环境中年轻人暴露前和暴露后的疫苗接种政策时，必须考虑这种免疫力水平的下降。
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