Saadatian-Elahi M, Mekki Y, Del Signore C, Lina B, Derrough T, Caulin E, Thierry J, Vanhems P
Laboratoire d'Epidémiologie et de Santé Publique, Université de Lyon, F-69003, Lyon, France.
Eur J Epidemiol. 2007;22(6):405-9. doi: 10.1007/s10654-007-9136-z. Epub 2007 May 30.
The purpose of the study was to calculate the seroprevalence of immunity to the varicella-zoster virus (VZV) infection and to evaluate the positive predictive value (PPV) and the negative predictive value (NPV) of the self-reported history of VZV infection in pregnant women. A cross sectional study was conducted in 18 private medical analysis laboratories. Information on socio-demographic characteristics and past history of varicella or zoster were collected using a questionnaire. Blood samples were obtained to determine the serological levels of past exposure to VZV. Overall, 486 pregnant women were recruited. The seroprevalence of VZV antibodies was 98.8%. Six women were seronegative, of whom four were primiparous. The PPV was high (99.5%) while the NPV was only 10.3%. The PPV is a reliable marker of prior VZV infection. In contrast, a negative history does not predict lack of immunity and should be completed by serological analysis which might be introduced to routine antenatal blood tests.
该研究的目的是计算对水痘-带状疱疹病毒（VZV）感染的免疫血清阳性率，并评估孕妇自我报告的VZV感染病史的阳性预测值（PPV）和阴性预测值（NPV）。在18家私立医学分析实验室进行了一项横断面研究。使用问卷收集社会人口学特征以及水痘或带状疱疹既往史的信息。采集血样以确定既往接触VZV的血清学水平。总共招募了486名孕妇。VZV抗体的血清阳性率为98.8%。6名女性血清学阴性，其中4名是初产妇。PPV较高（99.5%），而NPV仅为10.3%。PPV是既往VZV感染的可靠标志物。相比之下，阴性病史并不能预测缺乏免疫力，应该通过血清学分析来完善，血清学分析可引入常规产前血液检查。
