Donkó Agnes, Péterfi Zalán, Sum Adrienn, Leto Thomas, Geiszt Miklós
Faculty of Medicine, Semmelweis University Department of Physiology PO Box 259, 1444 Budapest, Hungary.
Philos Trans R Soc Lond B Biol Sci. 2005 Dec 29;360(1464):2301-8. doi: 10.1098/rstb.2005.1767.
Reactive oxygen species (ROS) have an important role in various physiological processes including host defence, mitogenesis, hormone biosynthesis, apoptosis and fertilization. Currently, the most characterized ROS-producing system operates in phagocytic cells, where ROS generated during phagocytosis act in host defence. Recently, several novel homologues of the phagocytic oxidase have been discovered and this protein family is now designated as the NOX/DUOX family of NADPH oxidases. NOX/DUOX enzymes function in a variety of tissues, including colon, kidney, thyroid gland, testis, salivary glands, airways and lymphoid organs. Importantly, members of the enzyme family are also found in non-mammalian species, including Caenorhabditis elegans and sea urchin. The physiological functions of novel NADPH oxidase enzymes are currently largely unknown. This review focuses on our current knowledge about dual oxidases.
活性氧(ROS)在包括宿主防御、有丝分裂原生成、激素生物合成、细胞凋亡和受精在内的各种生理过程中发挥着重要作用。目前,特征最明确的ROS产生系统存在于吞噬细胞中,吞噬过程中产生的ROS在宿主防御中发挥作用。最近,人们发现了几种吞噬氧化酶的新型同源物,这个蛋白质家族现在被命名为NADPH氧化酶的NOX/DUOX家族。NOX/DUOX酶在多种组织中发挥作用,包括结肠、肾脏、甲状腺、睾丸、唾液腺、气道和淋巴器官。重要的是,在包括秀丽隐杆线虫和海胆在内的非哺乳动物物种中也发现了该酶家族的成员。新型NADPH氧化酶的生理功能目前在很大程度上尚不清楚。本综述重点关注我们目前对双氧化酶的了解。