推定与利福布汀相关的葡萄膜炎的新眼部表现。

New ophthalmic manifestations of presumed rifabutin-related uveitis.

作者信息

Arevalo J F, Russack V, Freeman W R

机构信息

Department of Ophthalmology, Shiley Eye Center, University of California, a-San Diego, La Jolla 92093-0946, USA.

出版信息

Ophthalmic Surg Lasers. 1997 Apr;28(4):321-4.

PMID:9101573

Abstract

Rifabutin-related uveitis has been reported in AIDS patients who take a daily dose of 300 to 1800 mg of this drug. Presumed rifabutin-related uveitis is characterized by unilateral or bilateral anterior chamber inflammation with hypopyon accompanied by hyperemia, pain, photophobia, and vitritis. However, retinal manifestations or vitreous cytology of this entity have never been reported. This report describes a patient who had retinal vascular changes associated with uveitis while being treated with oral rifabutin. Fundus photographs and fluorescein angiograms documented resolved retinal vasculitis. Vitreous cytology of this case showed acute inflammatory cells. To the authors' knowledge, this is the first report of retinal vasculopathy in a patient with rifabutin-related uveitis and the first analysis of the vitreous cytologic aspects of this disease.

摘要

据报道，每日服用300至1800毫克利福布汀的艾滋病患者会出现与利福布汀相关的葡萄膜炎。推测与利福布汀相关的葡萄膜炎的特征是单侧或双侧前房炎症伴前房积脓，并伴有充血、疼痛、畏光和玻璃体炎。然而，该病症的视网膜表现或玻璃体细胞学情况从未有过报道。本报告描述了一名在接受口服利福布汀治疗期间出现与葡萄膜炎相关的视网膜血管变化的患者。眼底照片和荧光素血管造影记录了视网膜血管炎的消退情况。该病例的玻璃体细胞学检查显示有急性炎症细胞。据作者所知，这是首例关于利福布汀相关葡萄膜炎患者视网膜血管病变的报告，也是对该疾病玻璃体细胞学方面的首次分析。