Knewitz Marcos A, Mombach José C M
Laboratório de Bioinformática e Biologia Computacional, Centro de Ciências Exatas e Tecnológicas, Universidade doVale do Rio dos Sinos, 93022-000 São Leopoldo, RS, Brazil.
Comput Biol Med. 2006 Jan;36(1):59-69. doi: 10.1016/j.compbiomed.2004.08.002. Epub 2004 Dec 15.
We investigate the influence of cellular adhesion on the morphology of the interface between a tissue of proliferating and quiescent cells using the cellular Potts model. We show that a decrease in surface tension changes the morphology of the interface and that only for negative surface tensions cell detachment from the proliferative tissue occurs suggesting that this might be a necessary condition for metastatization in malignant neoplasies.
我们使用细胞Potts模型研究细胞黏附对增殖细胞和静止细胞组织之间界面形态的影响。我们发现表面张力的降低会改变界面形态，并且只有在表面张力为负时，细胞才会从增殖组织中脱离，这表明这可能是恶性肿瘤转移的必要条件。
