Morrison D C, Roser J F, Cochrane C G, Henson P M
J Immunol. 1975 Mar;114(3):966-70.
The low molecular weight mast cell activator, polymyxin B, has been covalently bound to an insoluble matrix of Sepharose 4B. It has been demonstrated that mast cells in preparations of rat peritoneal cells bind to Sepharose 4B-polymyxin B beads but not to control beads. The bound cells are stimulated to degranulate by this interaction at the cell membrane with the resultant release of biogenic amines.
低分子量肥大细胞激活剂多粘菌素B已共价结合到琼脂糖4B的不溶性基质上。业已证明，大鼠腹膜细胞制剂中的肥大细胞与琼脂糖4B-多粘菌素B珠粒结合，但不与对照珠粒结合。通过细胞膜上的这种相互作用，结合的细胞受到刺激而脱颗粒，从而释放生物胺。
