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[Production of IL-1 like cytokine by cultured bone cells: inducing effect of Haemophilus actinomycetemcomitans lipopolysaccharide on the cytokine production].[培养的骨细胞产生白细胞介素-1样细胞因子：伴放线放线杆菌脂多糖对细胞因子产生的诱导作用]
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Lipopolysaccharide: neutralization by polymyxin B shuts down the signaling pathway of nuclear factor kappaB in peripheral blood mononuclear cells, even during activation.脂多糖：即使在激活过程中，多粘菌素B的中和作用也会关闭外周血单核细胞中核因子κB的信号通路。
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Aggregatibacter actinomycetemcomitans, a potent immunoregulator of the periodontal host defense system and alveolar bone homeostasis.伴放线聚集杆菌，是牙周宿主防御系统和牙槽骨稳态的强效免疫调节剂。
Mol Oral Microbiol. 2016 Jun;31(3):207-27. doi: 10.1111/omi.12119. Epub 2015 Sep 22.

本文引用的文献

1
Characterization of the lipopolysaccharide from Actinobacillus actinomycetemcomitans Y4 and N27.伴放线放线杆菌Y4和N27脂多糖的特性分析
Infect Immun. 1980 Dec;30(3):862-73. doi: 10.1128/iai.30.3.862-873.1980.
2
Bacterial endotoxin: a role in chronic inflammatory periodontal disease?细菌内毒素：在慢性炎症性牙周病中起作用？
J Oral Pathol. 1980 Jan;9(1):1-15. doi: 10.1111/j.1600-0714.1980.tb01383.x.
3
A bioassay method in vitro for parathyroid hormone.一种甲状旁腺激素的体外生物测定方法。
J Endocrinol. 1969 Jan;43(1):33-46.
4
Neutralization of the Shwartzman reactions by polymyxins B.多粘菌素B对施瓦茨曼反应的中和作用。
J Immunol. 1967 Sep;99(3):564-9.
5
Endotoxin-induced intravascular coagulation: prevention with polymyxin B sulfate.内毒素诱导的血管内凝血：用硫酸多粘菌素B预防。
J Lab Clin Med. 1971 May;77(5):802-10.
6
Prevention by polymyxin B of endotoxin lethality in mice.多粘菌素B对小鼠内毒素致死性的预防作用。
J Bacteriol. 1967 Apr;93(4):1463-4. doi: 10.1128/jb.93.4.1463-1464.1967.
7
Bone resorbing activity of purified capsular material from Actinobacillus actinomycetemcomitans.伴放线放线杆菌纯化荚膜物质的骨吸收活性
J Periodontal Res. 1985 Sep;20(5):484-91. doi: 10.1111/j.1600-0765.1985.tb00831.x.
8
Polymyxin B sulfate modification of bacterial endotoxin: effects on the development of endotoxin shock in dogs.硫酸多粘菌素B对细菌内毒素的修饰：对犬内毒素休克发展的影响
Infect Immun. 1979 Mar;23(3):660-4. doi: 10.1128/iai.23.3.660-664.1979.
9
Binding of polymyxin B to the lipid A portion of bacterial lipopolysaccharides.多粘菌素B与细菌脂多糖的脂质A部分的结合。
Immunochemistry. 1976 Oct;13(10):813-8. doi: 10.1016/0019-2791(76)90181-6.
10
The initiation of mast cell degranulation: activation at the cell membrane.肥大细胞脱颗粒的起始：细胞膜上的激活
J Immunol. 1975 Mar;114(3):966-70.

多粘菌素B对脂多糖诱导的骨吸收的体外抑制作用

In vitro inhibition of lipopolysaccharide-induced bone resorption by polymyxin B.

作者信息

Harvey W, Wilson M, Meghji S

出版信息

Br J Exp Pathol. 1986 Oct;67(5):699-705.

PMID:3024692
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2012952/
Abstract

Lipopolysaccharide (LPS) purified from Haemophilus actinomycetemcomitans stimulates resorption and inhibits collagen synthesis in mouse calvaria bones in vitro. Addition of polymyxin B caused a dose-related inhibition of LPS-stimulated bone resorption and reversal of the inhibition of collagen synthesis. A polymyxin B to LPS ratio of 2:1 prevented bone resorption and restored collagen synthesis to control levels. The activity of polymyxin B was specific for LPS as bone resorption induced by prostaglandin E2 or parathyroid hormone was unaffected at similar concentrations. These results indicate that polymyxin B and its analogues may have potential in the treatment of periodontal disease by reducing bone loss induced by lipopolysaccharides.

摘要

从伴放线放线杆菌中纯化的脂多糖（LPS）在体外刺激小鼠颅骨骨吸收并抑制胶原蛋白合成。添加多粘菌素B会导致LPS刺激的骨吸收呈剂量相关抑制，并逆转胶原蛋白合成的抑制作用。多粘菌素B与LPS的比例为2:1可防止骨吸收并使胶原蛋白合成恢复到对照水平。多粘菌素B的活性对LPS具有特异性，因为在相似浓度下，前列腺素E2或甲状旁腺激素诱导的骨吸收不受影响。这些结果表明，多粘菌素B及其类似物可能通过减少脂多糖诱导的骨质流失而在牙周病治疗中具有潜力。