Synthesis and antiproliferative activities of diversely substituted glycosyl-isoindigo derivatives.
作者信息
Sassatelli Mathieu, Bouchikhi Fadoua, Messaoudi Samir, Anizon Fabrice, Debiton Eric, Barthomeuf Chantal, Prudhomme Michelle, Moreau Pascale
机构信息
Laboratoire SEESIB, Université Blaise-Pascal, UMR 6504 du CNRS, 24, avenue des Landais, 63177 Aubière, France.
出版信息
Eur J Med Chem. 2006 Jan;41(1):88-100. doi: 10.1016/j.ejmech.2005.10.004. Epub 2005 Dec 5.
In the course of structure-activity relationship studies, diversely substituted 1-(beta-D-glucopyranosyl)-isoindigo derivatives were prepared from commercially available indolines. Their antiproliferative activities were evaluated toward a panel of human solid cancer cell lines (PC 3, DLD-1, MCF-7, M4Beu, A549, PA 1), a murine cell line (L929) and a human fibroblast primary culture to get an insight into the substitution pattern required for the best biological potencies.
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