Crommen J H, Schacht E H, Mense E H
Laboratory of Organic Chemistry, University of Ghent, Belgium.
Biomaterials. 1992;13(8):511-20. doi: 10.1016/0142-9612(92)90102-t.
Polyphosphazenes with hydrolytic labile substituents have potential as biodegradable materials. By proper choice of the substituents, polymers can be prepared which degrade in vivo to form harmless products. The rate of biodegradation and the nature of the degradation products can be varied by changing the chemical composition of the polymers. A series of new degradable polyphosphazene derivatives are described. The synthesis of phosphazene polymers with various amounts of ethyl 2-(O-glycyl)lactate or ethyl 2-(O-alanyl)lactate as cosubstituents is described. These polymers are prepared by reaction of poly[(dichloro)phosphazene) with the corresponding amine compound. Total halogen replacement was achieved by subsequent introduction of glycine ethyl ester cosubstituents. Introduction of these hydrolysis-sensitive side-groups along the polymer chain increases the degradability of poly[(amino acid ester]phosphazenes).
带有水解不稳定取代基的聚磷腈有潜力成为可生物降解材料。通过适当选择取代基，可以制备出在体内降解形成无害产物的聚合物。通过改变聚合物的化学组成，可以改变生物降解速率和降解产物的性质。本文描述了一系列新型可降解聚磷腈衍生物。阐述了以不同量的2-(O-甘氨酰基)乳酸乙酯或2-(O-丙氨酰基)乳酸乙酯作为共取代基的磷腈聚合物的合成方法。这些聚合物是通过聚[(二氯)磷腈]与相应的胺化合物反应制备的。随后引入甘氨酸乙酯共取代基实现了完全卤素取代。沿着聚合物链引入这些对水解敏感的侧基提高了聚[(氨基酸酯)磷腈]的可降解性。
