Wilfert Sandra, Iturmendi Aitziber, Schoefberger Wolfgang, Kryeziu Kushtrim, Heffeter Petra, Berger Walter, Brüggemann Oliver, Teasdale Ian
Institute of Polymer Chemistry, Johannes Kepler University Linz, Welser Street 42, 4060 Leonding, Austria.
Institute of Organic Chemistry, Johannes Kepler University Linz, Altenberger Street 69, 4040 Linz, Austria ; Faculty of Science, University of South Bohemia, Branišovská 31, 370 05 České Budějovice, Czech Republic.
J Polym Sci A Polym Chem. 2014 Jan 15;52(2):287-294. doi: 10.1002/pola.27002.
The synthesis of a series of novel, water-soluble poly(organophosphazenes) prepared via living cationic polymerization is presented. The degradation profiles of the polyphosphazenes prepared are analyzed by GPC, P NMR spectroscopy, and UV-Vis spectroscopy in aqueous media and show tunable degradation rates ranging from days to months, adjusted by subtle changes to the chemical structure of the polyphosphazene. Furthermore, it is observed that these polymers demonstrate a pH-promoted hydrolytic degradation behavior, with a remarkably faster rate of degradation at lower pH values. These degradable, water soluble polymers with controlled molecular weights and structures could be of significant interest for use in aqueous biomedical applications, such as polymer therapeutics, in which biological clearance is a requirement and in this context cell viability tests are described which show the non-toxic nature of the polymers as well as their degradation intermediates and products.
本文介绍了通过活性阳离子聚合制备的一系列新型水溶性聚（有机磷腈）。通过凝胶渗透色谱（GPC）、磷核磁共振光谱（P NMR）和紫外可见光谱对所制备的聚磷腈在水性介质中的降解情况进行了分析，结果表明，通过对聚磷腈化学结构进行细微改变，其降解速率可在数天至数月范围内进行调节。此外，观察到这些聚合物表现出pH促进的水解降解行为，在较低pH值下降解速率明显更快。这些具有可控分子量和结构的可降解水溶性聚合物在水性生物医学应用中可能具有重要意义，例如聚合物疗法，其中生物清除是一项要求，在此背景下描述了细胞活力测试，结果表明这些聚合物及其降解中间体和产物具有无毒性质。
