Springer G F, Desai P R, Banatwala I
J Natl Cancer Inst. 1975 Feb;54(2):335-9.
Blood group M and N active substances were demonstrated in human mammary gland tissue in both benign and malignant lesions. The precursor T (Thomsen-Friedenreich) antigen occurred only in cancerous tissue, where it was found regularly in the 15 gross cancers tested. The precursor Tn antigen also was found regularly in cancerous breast tissue; Both antigens were reactive in breasts with in situ carcinoma. The T antigen was not demonstrable in the 6 benign mammary glands studied; similarly, the Tn antigen was unmasked by sialidase treatment of healthy breast tissues. Anti-T antibody, present in all human sera, was severely depressed in many breast cancer patients compared to controls.
在人类乳腺组织的良性和恶性病变中均证实存在血型M和N活性物质。前体T（汤姆森－弗里德赖希）抗原仅出现在癌组织中，在所检测的15例大体癌标本中均能经常发现该抗原。前体Tn抗原也经常在乳腺癌组织中发现；两种抗原在原位癌的乳腺中均具有反应活性。在所研究的6例良性乳腺中未证实有T抗原；同样，通过唾液酸酶处理健康乳腺组织也未发现Tn抗原。与对照组相比，所有人类血清中均存在的抗T抗体在许多乳腺癌患者体内显著降低。
