Koyama M, Uejima K, Konishi T, Ishida M, Kato M, Nishigaki M, Mizutani H, Matsumoto K, Kawase M, Tamaki T
National Sengokuso Hospital, Kaizuka, Japan.
Intern Med. 1992 Apr;31(4):496-9. doi: 10.2169/internalmedicine.31.496.
A 66-year-old Japanese male with diffuse non-Hodgkin's lymphoma, of the pleomorphic type, complicated with Klinefelter's syndrome is reported. His phisique was characterized by a long arm span, disproportionately longer lower body dimensions and a small sized penis. He had no children. Chromosomal study revealed 47, XXY and hormonal quantification showed hypergonadtropic hypogonadism. Although chemotherapy was administered, his disease took a progressive course and he died. A discussion of chromosomal alteration and oncogenesis and review of the literature are included.
报告了一名66岁的日本男性，患有弥漫性多形性非霍奇金淋巴瘤，并伴有克兰费尔特综合征。他的体格特征为臂展长、下身尺寸不成比例地长且阴茎短小。他没有子女。染色体研究显示为47, XXY，激素定量显示为高促性腺激素性性腺功能减退。尽管进行了化疗，他的病情仍呈进展性，最终死亡。文中还包括对染色体改变与肿瘤发生的讨论以及文献综述。
