Bradstock K, Clancy R, Uther J, Basten A, Richards J
Aust N Z J Med. 1978 Apr;8(2):176-9. doi: 10.1111/j.1445-5994.1978.tb04507.x.
A patient with primary amyloidosis is described with extensive vital organ involvement including infiltration of the liver, kidney and myocardium. Treatment with intermittent melphalan and prednisone resulted in improved hepatic and renal function, a reduction in liver size and arrested amyloid deposition in the myocardium. These observations suggest that chemotherapy can halt tissue amyloid deposition, and improve the prognosis of primary amyloidosis.
本文描述了一名原发性淀粉样变性患者，其重要脏器广泛受累，包括肝脏、肾脏和心肌浸润。采用间歇性美法仑和泼尼松治疗后，肝功能和肾功能得到改善，肝脏体积缩小，心肌淀粉样沉积停止。这些观察结果表明，化疗可以阻止组织淀粉样沉积，并改善原发性淀粉样变性的预后。
