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[肾肿瘤的经皮热消融术]

[Percutaneous thermal ablation of renal neoplasms].

作者信息

Tacke J, Mahnken A H, Günther R W

机构信息

Institut für Diagnostische und Interventionelle Radiologie/Neuroradiologie, Klinikum Passau.

出版信息

Rofo. 2005 Dec;177(12):1631-40. doi: 10.1055/s-2005-858819.

DOI:10.1055/s-2005-858819
PMID:16333785
Abstract

Due to modern examination techniques such as multidetector computed tomography and high-field magnetic resonance imaging, the detection rate of renal neoplasms is continually increasing. Even though tumors exceeding 4 cm in diameter rarely metastasize, all renal lesions that are possible neoplasms should be treated. Traditional treatment techniques include radical nephrectomy or nephron-sparing resection, which are increasingly performed laparoscopically. Modern thermal ablation techniques such as hyperthermal techniques like radiofrequency ablation RFA, laser induced thermal ablation LITT, focused ultrasound FUS and microwave therapy MW, as well as hypothermal techniques (cryotherapy) may be a useful treatment option for patients who are unfit for or refuse surgical resection. Cryotherapy is the oldest and best known thermal ablation technique and can be performed laparoscopically or percutaneously. Since subzero temperatures have no antistyptic effect, additional maneuvers must be performed to control bleeding. Percutaneous cryotherapy of renal tumors is a new and interesting method, but experience with it is still limited. Radiofrequency ablation is the most frequently used method. Modern probe design allows volumes between 2 and 5 cm in diameter to be ablated. Due to hyperthermal tract ablation, the procedure is deemed to be safe and has a low complication rate. Although there are no randomized comparative studies to open resection, the preliminary results for renal RFA are promising and show RFA to be superior to other thermal ablation techniques. Clinical success rates are over 90 % for both, cryo- and radiofrequency ablation. Whereas laser induced thermal therapy is established in hepatic ablation, experience is minimal with respect to renal application. For lesions of more than 2 cm in diameter, additional cooling catheters are required. MR thermometry offers temperature control during ablation. Microwave ablation is characterized by small ablation volumes and plays a role as a coagulation tool during resection. Focused ultrasound is the only non-invasive method, but it is still experimental.

摘要

由于多排螺旋计算机断层扫描和高场磁共振成像等现代检查技术的应用,肾肿瘤的检出率持续上升。尽管直径超过4厘米的肿瘤很少发生转移,但所有可能为肿瘤的肾脏病变均应予以治疗。传统治疗技术包括根治性肾切除术或保留肾单位切除术,现在越来越多地通过腹腔镜进行。现代热消融技术,如射频消融(RFA)、激光诱导热消融(LITT)、聚焦超声(FUS)和微波治疗(MW)等高热技术,以及低温技术(冷冻疗法),对于不适合或拒绝手术切除的患者可能是一种有用的治疗选择。冷冻疗法是最古老且最知名的热消融技术,可通过腹腔镜或经皮进行。由于零下温度没有止血作用,必须采取额外措施来控制出血。经皮肾肿瘤冷冻疗法是一种新的有趣方法,但相关经验仍有限。射频消融是最常用的方法。现代探头设计可消融直径2至5厘米的体积。由于高温通道消融,该手术被认为是安全的,并发症发生率低。尽管尚无与开放切除术的随机对照研究,但肾射频消融的初步结果很有前景,显示其优于其他热消融技术。冷冻消融和射频消融的临床成功率均超过90%。激光诱导热疗法在肝脏消融中已得到应用,但在肾脏应用方面经验极少。对于直径超过2厘米的病变,需要额外的冷却导管。磁共振测温可在消融过程中进行温度控制。微波消融的特点是消融体积小,在切除过程中起凝固工具的作用。聚焦超声是唯一的非侵入性方法,但仍处于实验阶段。

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